Smyth Lab

About The Smyth Lab

The Smyth Lab research composes of Drug Delivery, Formulation Science, and Pharmaceutical Engineering. Researchers focus on the development of novel methods for drug delivery including inhalation, nasal, transdermal, ophthalmic, and oral delivery systems for a variety of diseases. Translation of these technologies to the clinic is the long-term goal of the Lab and is supported by developing a mechanistic understanding of the complex physical and biological systems.

2023 Research

Lou H, Ding L, Wu T, Li W, Khalaf R, Smyth HDC, Reid DL. Emerging Process Modeling Capabilities for Dry Powder Operations for Inhaled Formulations. Mol Pharm. 2023 Nov 6;20(11):5332-5344. Epub 2023 Oct 2. PMID: 37783568.
Liao Y, Wang H, Li S, Xue Y, Chen Y, Adu-Frimpong M, Xu Y, Yu J, Xu X, Smyth HDC, Zhu Y. Preparation of astaxanthin-loaded composite micelles with coaxial electrospray technology for enhanced oral bioavailability and improved antioxidation capability. J Sci Food Agric. 2023 Oct 2. Epub ahead of print. PMID: 37782057.
Nair VV, Smyth HDC. Inhalable Excipient-Free Dry Powder of Tigecycline for the Treatment of Pulmonary Infections. Mol Pharm. 2023 Aug 22. Epub ahead of print. PMID: 37606919.
Behrend-Keim B, Castro-Muñoz A, Monrreal-Ortega L, Ávalos-León B, Campos- Estrada C, Smyth HDC, Bahamondez-Canas TF, Moraga-Espinoza D. The forgotten material: Highly dispersible and swellable gelatin-based microspheres for pulmonary drug delivery of cromolyn sodium and ipratropium bromide. Int J Pharm. 2023 Aug 17:123331. Epub ahead of print. PMID: 37597595.
Warnken Z, Trementozzi A, Martins PP, Parekh J, Koleng JJ, Smyth HDC, Brunaugh A. Development of low-cost, weight-adjustable clofazimine mini-tablets for treatment of tuberculosis in pediatrics. Eur J Pharm Sci. 2023 May 18;187:106470. Epub ahead of print. PMID: 37207942.
Y, Liao Y, Wang H, Li S, Gu Z, Adu-Frimpong M, Yu J, Xu X, Smyth HDC, Zhu Y. Preparation and evaluation of astaxanthin-loaded 2-hydroxypropyl-beta- cyclodextrin and Soluplus® nanoparticles based on electrospray technology. J Sci Food Agric. 2023 May;103(7):3628-3637. Epub 2023 Mar 7. PMID: 36840513.

2022 Research

Ren A, Koleng JJ 3rd, Costello M, Spahn JE, Smyth HDC, Zhang F. Twin-screw continuous mixing can produce dry powder inhalation mixtures for pulmonary delivery. J Pharm Sci. 2022 Oct 10:S0022-3549(22)00460-9. . Epub ahead of print. PMID: 36228755.
Brunaugh AD, Walz A, Warnken Z, Pearce C, Munoz Gutierrez J, Koleng JJ, Smyth HDC, Gonzalez-Juarrero M. Respirable Clofazimine Particles Produced by Air Jet Milling Technique Are Efficacious in Treatment of BALB/c Mice with Chronic Mycobacterium tuberculosis Infection. Antimicrob Agents Chemother. 2022 Sep 20;66(9):e0018622. Epub 2022 Aug 9. PMID: 35943265; PMCID: PMC9487480.
Spahn JE, Hefnawy A, Smyth HDC, Zhang F. Development of a novel method for the continuous blending of carrier-based dry powders for inhalation using a co- rotating twin-screw extruder. Int J Pharm. 2022 Jul 25;623:121914. Epub 2022 Jun 16. PMID: 35716975.
Zhu Y, Gu Z, Liao Y, Li S, Xue Y, Firempong MA, Xu Y, Yu J, Smyth HD, Xu X. Improved intestinal absorption and oral bioavailability of astaxanthin using poly (ethylene glycol)-graft-chitosan nanoparticles: preparation, in vitro evaluation, and pharmacokinetics in rats. J Sci Food Agric. 2022 Feb;102(3):1002-1011. Epub 2021 Aug 13. PMID: 34312873.
JE Spahn, F Zhang, HDC Smyth. Mixing of dry powders for inhalation: A review. International Journal of Pharmaceutics, 121736. May 10, 2022.
AN Trementozzi, C Zhao, H Smyth, Z Cui, JC Stachowiak. Gap Junction-Mediated Delivery of Polymeric Macromolecules. ACS Biomaterials Science & Engineering 8 (4), 1566-1572. March 10, 2022.
NE Ceschan, S Scioli-Montoto, ML Sbaraglini, ME Ruiz, HDC Smyth, ...Nebulization of a polyelectrolyte-drug system for systemic hypertension treatment. European Journal of Pharmaceutical Sciences 170, 106108. March 1, 2022.
AD Brunaugh, L Ding, T Wu, M Schneider, R Khalaf, HDC Smyth. Identification of Stability Constraints in the Particle Engineering of an Inhaled Monoclonal Antibody Dried Powder. Journal of Pharmaceutical Science. February 2022.
AD Brunaugh, L Ding, T Wu, M Schneider, R Khalaf, HDC Smyth. Identification of stability constraints in the particle engineering of an inhaled monoclonal antibody dried powder. Journal of Pharmaceutical Sciences 111 (2), 403-416. February 2, 2022.
CL Domínguez-Delgado, Z Akhtar, G Awuah-Mensah, B Wu, HDC Smyth. Effects of Process and Formulation Parameters on Submicron Polymeric Particles Produced by a Rapid Emulsion-Diffusion Method. Nanomaterials 12 (2), 229. January 11, 2022.
L Ding, AD Brunaugh, R Thakkar, C Lee, QJ Zhao, J Kalafat, ... Comparison of HPMC Inhalation-Grade Capsules and Their Effect on Aerosol Performance Using Budesonide and Rifampicin DPI Formulations. AAPS PharmSciTech 23 (1), 1-13. January 11, 2022.

2021 Research

L Ding, S Cai, J Wang, H Smyth. 481: PEGylated tobramycin significantly improves anti-biofilm activity in vitro and in vivo. Journal of Cystic Fibrosis 20, S226-S2282021. January 11, 2021.
MV Ramírez‐Rigo, NE Ceschan, HDC Smyth. Controlled Drug Delivery via the Lung. Fundamentals of Drug Delivery, 449-4692021. October 26, 2021.
KK Arafa, HDC Smyth, IM El-Sherbiny. Mitotropic triphenylphosphonium doxorubicin-loaded core-shell nanoparticles for cellular and mitochondrial sequential targeting of breast cancer. International Journal of Pharmaceutics 606, 1209362021. September 5, 2021.
H Zhang, Y Zhang, RO Williams III, HDC Smyth. Development of PEGylated chitosan/CRISPR-Cas9 dry powders for pulmonary delivery via thin-film freeze-drying. International Journal of Pharmaceutics 605, 1208312021. August 10, 2021.
L Ding, AD Brunaugh, S Stegemann, SV Jermain, MJ Herpin, J Kalafat, ... A Quality by Design Framework for Capsule-Based Dry Powder Inhalers. Pharmaceutics 2021, 13, 1213. August 6, 2021.
Y Zhu, Z Gu, Y Liao, S Li, Y Xue, MA Firempong, Y Xu, J Yu, HDC Smyth, ... Improved intestinal absorption and oral bioavailability of astaxanthin using poly (ethylene glycol)‐graft‐chitosan nanoparticles: preparation, in vitro evaluation, and … Journal of the Science of Food and Agriculture. July 26, 2021.
L Ding, AD Brunaugh, S Stegemann, SV Jermain, MJ Herpin, J Kalafat, ... A Quality by Design Framework for Capsule-Based Dry Powder Inhalers. Pharmaceutics 13 (8), 121312021. July 10, 2021.
MD Hall, JM Anderson, A Anderson, D Baker, J Bradner, KR Brimacombe, ... Report of the national institutes of health SARS-CoV-2 antiviral therapeutics summit. The Journal of infectious diseases 224 (Supplement_1), S1-S2192021. June 10, 2021.
L Ding, J Wang, S Cai, H Smyth, Z Cui Pulmonary Biofilm-Based Chronic Infections and Inhaled Treatment Strategies. International Journal of Pharmaceutics 604, 12076822021. July 15, 2021.
AK Hewavitharana, PN Shaw, HDC Smyth, LP Samaranayake, ... The Importance of Complete Overlapping of Analyte and Internal Standard Peaks in Eliminating Matrix Effects with Liquid Chromatography--Mass Spectrometry (LC--MS). LC-GC North America 39 (7), 335-3392021. July 1, 2021.
A Anzueto, HDC Smyth. Letter to the Editor in response to the article:“Nebulization: a potential source of SARS-CoV-2 transmission”. Respiratory Medicine and Research 79, 1008022021. May 2021.
JL Wang, MS Hanafy, H Xu, J Leal, Y Zhai, D Ghosh, RO Williams Iii, ... Aerosolizable siRNA-encapsulated solid lipid nanoparticles prepared by thin-film freeze-drying for potential pulmonary delivery. International Journal of Pharmaceutics 596, 12021562021. March 1, 2021.
AD Brunaugh, H Seo, Z Warnken, L Ding, SH Seo, HDC Smyth. Development and evaluation of inhalable composite niclosamide-lysozyme particles: A broad-spectrum, patient-adaptable treatment for coronavirus infections and sequalae PloS one 16 (2), e0246803132021. February 11, 2021.
AD Brunaugh, S Sharma, H Smyth. Inhaled fixed-dose combination powders for the treatment of respiratory infections. Expert Opinion on Drug Delivery, 1-1542021. February 1, 2021.
SMH Shah, SMM Shah, S Khan, F Ullah, SWA Shah, M Ghias, M Shahid, ... Efficient design to fabricate smart Lumefantrine nanocrystals using DENA® particle engineering technology: Characterisation, in vitro and in vivo antimalarial evaluation and … Journal of Drug Delivery Science and Technology 61, 10222822021. February 2021.
SC Das, P Khadka, R Shah, S McGill, HDC Smyth. Nanomedicine in pulmonary delivery. Theory and Applications of Nonparenteral Nanomedicines, 319-35412021. January 2021.

2020 Research

Z Warnken, Y Lu, HDC Smyth, RO Williams. Nose-to-Brain Drug Delivery Enabled by Nanocarriers. Nanomedicines for Brain Drug Delivery, 209-2332021. November 20, 2020.
HS Syed Muhammad, SM Mukarram Shah, S Khan, F Ullah, SW Ali Shah, ... Efficient design to fabricate smart Lumefantrine nanocrystals using DENA® particle engineering technology: Characterisation, in vitro and in vivo antimalarial evaluation and … Elsevier. November 11, 2020.
H Zhang, J Leal, MR Soto, HDC Smyth, D Ghosh. Aerosolizable Lipid Nanoparticles for Pulmonary Delivery of mRNA through Design of Experiments. Pharmaceutics 12 (11), 1042102020. October 20, 2020.
AD Brunaugh, H Seo, Z Warnken, L Ding, SH Seo, HDC Smyth. Broad-spectrum, patient-adaptable inhaled niclosamide-lysozyme particles are efficacious against coronaviruses in lethal murine infection models. bioRxiv. October 7, 2020.
J Leal, H Zhang, M Soto, HD Smyth, D Ghosh. DEVELOPMENT OF LIPID NANOPARTICLES WITH DESIGN OF EXPERIMENTS FOR AEROSOLIZED PULMONARY DELIVERY OF MRNA. PEDIATRIC PULMONOLOGY 55, S240-S2412020. October 1, 2020.
AN Trementozzi, S Hufnagel, H Xu, MS Hanafy, F Rosero Castro, ... Gap junction liposomes for efficient delivery of chemotherapeutics to solid tumors. ACS Biomaterials Science & Engineering 6 (9), 4851-485712020. August 17, 2020.
H Xu, RF Alzhrani, ZN Warnken, SG Thakkar, M Zeng, HDC Smyth, ... Immunogenicity of Antigen Adjuvanted with AS04 and Its Deposition in the Upper Respiratory Tract after Intranasal Administration. Molecular Pharmaceutics 17 (9), 3259-326922020. August 10, 2020.
J Leal, X Peng, X Liu, D Arasappan, DC Wylie, SH Schwartz, JJ Fullmer, ... Peptides as surface coatings of nanoparticles that penetrate human cystic fibrosis sputum and uniformly distribute in vivo following pulmonary delivery. Journal of Controlled Release 322, 457-469122020. June 10, 2020.
F Tewes, TF Bahamondez-Canas, D Moraga-Espinoza, HDC Smyth, ... In vivo efficacy of a dry powder formulation of ciprofloxacin-copper complex in a chronic lung infection model of bioluminescent Pseudomonas aeruginosa. European Journal of Pharmaceutics and Biopharmaceutics 152, 210-21722020. July 2020.
AJ Hickey, HDC Smyth. Pharmaco-complexity. Springer International Publishing. June 2020.
AJ Hickey, HDC Smyth. Computational Modeling of Nonlinear Phenomena Using Machine Learning. Pharmaco-complexity, 53-622020. June 25, 2020.
AJ Hickey, HDC Smyth. Fractal Pharmacokinetics, Systems Pharmacology, Network Analysis, Multiscale, Kinetics, Toxicokinetics, Drug Safety. Pharmaco-complexity, 39-452020. June 25, 2020.
AJ Hickey, HDC Smyth. Considerations in Monitoring and Controlling Pharmaceutical Manufacturing. Pharmaco-complexity, 31-382020. June 25, 2020.
AJ Hickey, HDC Smyth. Phenomena in Physical and Surface Chemistry. Pharmaco-complexity, 5-162020. June 25, 2020.
AJ Hickey, HDC Smyth. Impact of Complexity on Population Biology. Pharmaco-complexity, 47-512020. June 25, 2020.
AJ Hickey, HDC Smyth. Solid-State Pharmaceuticals: Solving Complex Problems in Preformulation and Formulation. Pharmaco-complexity, 17-302020. June 25, 2020.
AJ Hickey, HDC Smyth. The Nature of Complexity and Relevance to Pharmaceutical Sciences. Pharmaco-complexity, 1-4. June 25, 2020.
J Leal, X Peng, X Liu, D Arasappan, DC Wylie, SH Schwartz, JJ Fullmer, ... Peptides as surface coatings of nanoparticles that penetrate human cystic fibrosis sputum and uniformly distribute in vivo following pulmonary delivery. Journal of Controlled Release 322, 457-469122020. June 10, 2020.
DA Davis, PP Martins, MS Zamloot, SA Kucera, RO Williams, HDC Smyth, ...Complex drug delivery systems: controlling transdermal permeation rates with multiple active pharmaceutical ingredients. AAPS PharmSciTech 21, 1-1142020. June 4, 2020.
X Zhang, X Yue, Y Cui, Z Zhao, Y Huang, S Cai, G Wang, W Wang, ... A systematic safety evaluation of nanoporous mannitol material as a dry-powder inhalation carrier system. Journal of pharmaceutical sciences 109 (5), 1692-170222020. May 2020.
L Ding, AD Brunaugh, C Lee, Q Zhao, J Kalafat, S Powale, J Bhat, ... COMPARISON OF COMMERCIALLY AVAILABLE HPMC INHALATION-GRADE CAPSULES AND EFFECT ON AEROSOL PERFORMANCE WITHIN MODEL DPI FORMULATIONS. JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY 33 (2), A3-A32020. April 4, 2020.
H Bandara, AK Hewavitharana, PN Shaw, HDC Smyth, ... A novel, quorum sensor-infused liposomal drug delivery system suppresses Candida albicans biofilms. International journal of pharmaceutics 578, 11909672020. March 30, 2020.
J Gu, JR Clegg, LA Heersema, NA Peppas, HDC Smyth. Optimization of Cationic Nanogel PEGylation to Achieve Mammalian Cytocompatibility with Limited Loss of Gram-Negative Bactericidal Activity. Biomacromolecules 21 (4), 1528-153842020. March 24, 2020.
S Sahakijpijarn, HDC Smyth, DP Miller, JG Weers. Post-inhalation cough with therapeutic aerosols: Formulation considerations. Advanced drug delivery reviews 165, 127-141152020. 2020.
LM Armijo, SJ Wawrzyniec, M Kopciuch, YI Brandt, AC Rivera, NJ Withers, ... Antibacterial activity of iron oxide, iron nitride, and tobramycin conjugated nanoparticles against Pseudomonas aeruginosa biofilms. Journal of nanobiotechnology 18 (1), 1-27382020. February 18, 2021.