About The Huibregtse Lab
The Huibregtse Lab studies the biochemistry of the ubiquitin proteolysis system and ISG15, a ubiquitin-like modifier involved in innate immune responses to viral and microbial infections. The Lab's current major iprojects include:
- The mechanism and function of ISG15 conjugation.
- ISG15's second biochemical function as an extracellular signaling protein.
- The role of the ubiquitin system in protein quality control, particularly the role of co-Translational Ubiquitination (CTU).
2023 Research
- Yuan F, Gollapudi S, Day KJ, Ashby G, Sangani A, Malady BT, Wang L, Lafer EM, Huibregtse JM, Stachowiak JC. Ubiquitin-driven protein condensation promotes clathrin-mediated endocytosis. bioRxiv [Preprint]. 2023 Aug 22:2023.08.21.554139. PMID: 37662320; PMCID: PMC10473642.
2021 Research
- CD Swaim, Y-C Perng, X Zhao, LA Canadeo, HH Harastani, TL Darling, ACM Boon, DJ Lenschow and JM Huibregtse. 6-Thioguanine Blocks SARS-CoV-2 Replication by Inhibition of PLpro. iScience. Volume 24, Issue 10, 103213. October 22, 2021.
2020 Research
- CD Swaim, LA Canadeo, KJ Monte, S Khanna, DJ Lenschow and JM Huibregtse. Modulation of extracellular ISG15 signaling by pathogens and viral effector proteins. Cell Reports 31:107772. June 16, 2020.
- T Tomita, JM Huibregtse and A Matouschek. A masked initiation region in retinoblastoma protein regulates its proteasomal degradation. Nature Commun. 11:2019. April 24, 2020.
- WW Ryu, R Stewart, C Pectol, N Ender, O Wimalarathne, JH Lee, CP Zanini, A Harvey, JM Huibregtse, P Mueller and T Paull. Comprehensive identification of HSP70/HSC70 chaperone clients in human cells. PLoS Biology 18:3000606. 2020.