Huibregtse Lab

About The Huibregtse Lab

The Huibregtse Lab studies the biochemistry of the ubiquitin proteolysis system and ISG15, a ubiquitin-like modifier involved in innate immune responses to viral and microbial infections.  The Lab's current major iprojects include:

  • The mechanism and function of ISG15 conjugation.
  • ISG15's second biochemical function as an extracellular signaling protein.  
  • The role of the ubiquitin system in protein quality control, particularly the role of co-Translational Ubiquitination (CTU).  


2023 Research

2021 Research

2020 Research